Asian Journal of Research in Chemistry

Abstract

A series of phthalimide derivatives were synthesized and evaluated for their analgesic and invitro antiinflammatory activity. The target compounds were obtained by condensation of N-hydroxymethylphthalimide with the substituted thiadiazole. The structures of the synthesized derivatives were confirmed by means of IR, ¹H-NMR spectral data. The analgesic activity was determined by acetic acid induced writhings in mice and Invitro antiinflammatory activity was evaluated using thermally induced protein denaturation technique. The results revealed the importance of the combination of thiadiazole and phthalimide moieties as a promising analgesic and antiinflammatory candidate.

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Abstract

In these study, a series of N²-substituted Dihydrophthalazine-1,4-dione Derivatives (2a-2o) were synthesized from phthalic anhydride and aromatic acid hydrazides (1a-1o) using microwave irradiation. The synthesized compounds were confirmed by IR and1H NMR studies. Synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock (MES) method. Neurologic deficit was evaluated by the rotarod test. All the compounds exhibited significant anticonvulsant activity. Compounds 2a, 2b, 2i and 2o were most active of the series against MESinduced seizures.

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